Selank

Selank at a glance

Selank is a synthetic seven-amino-acid peptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro. Its first four residues reproduce tuftsin, a short immunoactive fragment of the immunoglobulin G heavy chain; the trailing Pro-Gly-Pro motif was appended to slow breakdown by peptidases. The compound came out of Russian academic research and is registered as a medicine in Russia, though it has no approval in the United States or the European Union. Research supplies arrive as a white lyophilized powder.

Price and availability

A listing from Vital Edge Science, shipped from Australia. It is listed at $45.00. As with every order here, the brand is paid only after you confirm delivery.

What it is studied for

Proposed mechanisms span the nervous and immune systems. In rodent work, Selank has been reported to influence GABAergic transmission, possibly by modulating how GABA-A receptors respond to their ligands rather than occupying the benzodiazepine site directly. Other papers describe changes in serotonin and dopamine metabolism, shifts in hippocampal brain-derived neurotrophic factor expression, and inhibition of enkephalin-degrading enzymes, which would prolong endogenous opioid peptide signaling. On the immune side, its tuftsin heritage links it to macrophage activity, and studies have measured altered interleukin-6 and other cytokine transcripts. None of these pathways has been established as the primary mode of action.

Research and regulatory status

Most Selank papers originate from a small network of Russian institutions, and many appear in Russian-language journals. The published work includes rodent anxiety and memory paradigms, gene-expression studies, and small clinical reports in patients with anxiety disorders associated with its domestic registration. Independent Western replication remains limited, and large double-blind trials of the kind the FDA or EMA would require have not been reported. Outside Russia, it is treated as an investigational research compound.

Checking the lab data

A useful certificate confirms the seven-residue sequence by mass spectrometry, with the observed mass matching the theoretical value for Thr-Lys-Pro-Arg-Pro-Gly-Pro, and reports HPLC purity from a dated, batch-numbered run. Because related analogues such as N-acetyl variants are also sold, the report should state plainly whether the peptide is unmodified. The vial should hold a compact white or off-white lyophilized cake with no visible moisture or discoloration.

This listing has an independent lab report attached; the testing panel above summarises what the tested sample contained against its label.

Listing details

Compound

Selank

Synonyms

Tuftsin analogue

Class

Synthetic heptapeptide (tuftsin derivative)

Format

Lyophilized (freeze-dried) powder

Sold by

Vital Edge Science

Ships from

Australia

Lab report

Independent report attached

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.