Semax

Semax at a glance

Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. Its first four residues match the 4-7 segment of adrenocorticotropic hormone, and the added Pro-Gly-Pro tail slows breakdown by peptidases. It was developed by researchers at the Institute of Molecular Genetics in Moscow. Although it descends from ACTH, it is not treated as a hormonal peptide, because the shortened sequence no longer carries the adrenal-stimulating activity of the parent molecule.

Price and availability

Vital Edge Science lists this listing, shipped from Australia. It is listed at $45.00. As with every order here, the brand is paid only after you confirm delivery.

What it is studied for

Much of the mechanistic literature centers on neurotrophins. Rodent studies report that Semax raises levels of brain-derived neurotrophic factor and its receptor TrkB in the hippocampus and cortex, and gene-expression work after experimental ischemia describes shifts in inflammatory and vascular transcripts. Other papers propose effects on dopamine and serotonin turnover and possible interactions with melanocortin receptors, which would fit its ACTH ancestry. Antioxidant-like activity has also been described. How these observations connect, and which matter most, has not been settled, and the data come chiefly from animal tissue.

Research and regulatory status

Semax holds a different regulatory position from most catalogue peptides. Russian authorities list it as a registered medicine, supplied as nasal drops, and clinical reports from Russia cover stroke and cognitive disorders. Those studies are mostly small and published in Russian-language journals, which limits outside scrutiny. Semax has not been approved by the FDA or the EMA, and in the United States and Europe it is handled as an unapproved research compound with a largely preclinical evidence base.

Checking the lab data

Identity is best confirmed by mass spectrometry showing the mass expected for Met-Glu-His-Phe-Pro-Gly-Pro, with any N-acetyl or amidated variant stated explicitly when a vendor sells a modified form. HPLC purity should come from a chromatogram, not a bare figure. Because the sequence contains methionine, oxidized impurities are a known risk, so a clean main peak matters. Expect a white, intact lyophilized cake and a batch-matched, dated report.

An independent lab report is attached to this listing, and the panel above shows the measured result next to the labelled amount.

Listing details

Compound

Semax

Synonyms

ACTH(4-10) analog

Class

Synthetic ACTH-fragment neuropeptide

Format

Lyophilized (freeze-dried) powder

Sold by

Vital Edge Science

Ships from

Australia

Lab report

Independent report attached

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.