Name: Melanotan 1
Brand: Lilipeptide
SKU: LILI-melanotan-1
Price: 68.00 USD
Availability: InStock

Melanotan 1 at a glance

Melanotan 1 is a linear 13-amino-acid analogue of alpha-MSH developed at the University of Arizona. Two substitutions in the native sequence matter: norleucine replaces an oxidation-prone methionine, and D-phenylalanine replaces L-phenylalanine, increasing potency and resistance to enzymes. Its formula is C78H111N21O19 and its molecular weight 1646.8 g/mol. The international nonproprietary name for the same molecule is afamelanotide. Listings here are lyophilized research material, distinct from the regulated clinical implant.

Price and availability

A listing from Lilipeptide, shipped from China. It is listed at $68.00. Your payment waits in escrow until you confirm the parcel arrived, and only then is it released to the brand.

This listing: Lilipeptide Melanotan 1

Brand: Lilipeptide
Also sold by: Uther Peptide 10mg $60.00 · HK Peptide 10mg $50.00 · Sulan Bio 10mg $80.00 · Lab77 Peptides 10mg $50.00 · Cyprus Peptides 10mg $152.00 · TFC Peptides 10mg $45.00

Lab testing

There is no public lab report for this listing yet. We can ask the brand for the batch COA before you order. Many buyers also split an independent HPLC test with others who bought the same batch.

Request the batch COA · How group testing works

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

What it is studied for

The peptide is a potent agonist at the melanocortin-1 receptor on melanocytes. MC1R couples to Gs, so activation raises cAMP and switches on MITF-driven transcription of tyrosinase and related enzymes, steering melanocytes toward brown-black eumelanin instead of red-yellow pheomelanin. It also has lower but measurable activity at other melanocortin receptors. Research additionally examines whether MC1R signaling contributes to DNA-repair and antioxidant responses in skin cells beyond pigment production itself, a line of inquiry that remains under investigation.

Research and regulatory status

Afamelanotide has a regulated clinical record: controlled trials in erythropoietic protoporphyria supported approval in Europe and later in the United States, where the approved product is a dissolving implant used under medical supervision. Investigators have also studied it in vitiligo, polymorphic light eruption and other photodermatoses, with varying results. Research-grade Melanotan 1 is not that product. On GLP1 Forum Escrow it is listed for laboratory study, and its quality depends on each brand's synthesis and testing.

Checking the lab data

Identity should be confirmed by mass spectrometry consistent with 1646.8 g/mol, which also separates it from Melanotan 2, a smaller cyclic analogue with a very different mass. HPLC purity should be supported by a chromatogram and a stated method. The report should include peptide content per vial, the appearance of a white lyophilized cake, a batch number matching the label, and the name of the independent laboratory that ran the tests.

No independent report is attached to this listing yet. You can compare brands that publish one on the Melanotan 1 page or browse the lab reports directory.

Listing details

Compound: Melanotan 1
Synonyms: Afamelanotide
Class: Synthetic alpha-MSH analogue (13-amino-acid peptide)
Format: Lyophilized (freeze-dried) powder
Molecular formula: C78H111N21O19
Molecular weight: 1646.8 g/mol
Sold by: Lilipeptide
Ships from: China
Lab report: Not yet published

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Buyer questions

Why was norleucine substituted into the sequence?

Native alpha-MSH contains methionine, which oxidizes easily and can lose activity during storage or in biological fluids. Norleucine has a similar side-chain length without the sulfur atom, so it keeps the shape the receptor recognizes while removing that weak point. This kind of substitution is a common strategy in peptide design.

Is Melanotan 1 studied only for tanning?

No. Pigmentation is the most visible outcome, but research also covers photoprotection in light-sensitivity disorders, vitiligo repigmentation and the broader biology of melanocortin signaling in skin. Much of the human data comes from clinical work on afamelanotide rather than research-grade material, so the two should be kept distinct when reading studies.

When does Lilipeptide get paid?

Only after you confirm delivery. Until then the payment is held in escrow, and you can open a claim if anything is wrong with the order.

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.