Melanotan I (MT-1) 10mg

Melanotan 1 at a glance

Melanotan 1 is a linear 13-amino-acid analogue of alpha-MSH developed at the University of Arizona. Two substitutions in the native sequence matter: norleucine replaces an oxidation-prone methionine, and D-phenylalanine replaces L-phenylalanine, increasing potency and resistance to enzymes. Its formula is C78H111N21O19 and its molecular weight 1646.8 g/mol. The international nonproprietary name for the same molecule is afamelanotide. Listings here are lyophilized research material, distinct from the regulated clinical implant.

Price and availability

This is Lab77 Peptides‘s single 10mg vial, dispatched from the United States. At $50.00 for the kit, that works out to $5.00 per mg. Across 8 brands listing Melanotan 1 here, the middle half of prices falls between $0.479 and $0.80 per mg; this kit is above the typical range. Checkout goes into escrow first; the funds move to Lab77 Peptides once delivery is confirmed.

What it is studied for

The peptide is a potent agonist at the melanocortin-1 receptor on melanocytes. MC1R couples to Gs, so activation raises cAMP and switches on MITF-driven transcription of tyrosinase and related enzymes, steering melanocytes toward brown-black eumelanin instead of red-yellow pheomelanin. It also has lower but measurable activity at other melanocortin receptors. Research additionally examines whether MC1R signaling contributes to DNA-repair and antioxidant responses in skin cells beyond pigment production itself, a line of inquiry that remains under investigation.

Research and regulatory status

Afamelanotide has a regulated clinical record: controlled trials in erythropoietic protoporphyria supported approval in Europe and later in the United States, where the approved product is a dissolving implant used under medical supervision. Investigators have also studied it in vitiligo, polymorphic light eruption and other photodermatoses, with varying results. Research-grade Melanotan 1 is not that product. On GLP1 Forum Escrow it is listed for laboratory study, and its quality depends on each brand's synthesis and testing.

Checking the lab data

Identity should be confirmed by mass spectrometry consistent with 1646.8 g/mol, which also separates it from Melanotan 2, a smaller cyclic analogue with a very different mass. HPLC purity should be supported by a chromatogram and a stated method. The report should include peptide content per vial, the appearance of a white lyophilized cake, a batch number matching the label, and the name of the independent laboratory that ran the tests.

No independent report is attached to this listing yet. You can compare brands that publish one on the Melanotan 1 page or browse the lab reports directory.

Listing details

Compound

Melanotan 1

Synonyms

Afamelanotide

Class

Synthetic alpha-MSH analogue (13-amino-acid peptide)

Format

Lyophilized (freeze-dried) powder

Molecular formula

C78H111N21O19

Molecular weight

1646.8 g/mol

Vial strength

10mg

Total content

10 mg

Price per mg

$5.00

Sold by

Lab77 Peptides

Ships from

United States

Lab report

Not yet published

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Concentration arithmetic: one 10 mg vial dissolved in 2 mL gives 5 mg/mL, or 10 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.