PNC-27 30mg (10 Vials / Kit)

PNC-27 at a glance

PNC-27 is a hybrid peptide created by Matthew Pincus and colleagues in New York. Its N-terminal portion reproduces a stretch of the p53 tumor suppressor that docks with HDM-2, the human homolog of MDM2; its C-terminal portion is a membrane-residency sequence derived from the Antennapedia homeodomain, often called penetratin. The 32-residue construct has the formula C188H293N53O44S and a molecular weight of 4031.7 g/mol, and it is supplied as a lyophilized powder.

Price and availability

A kit of 10 vials at 30mg each (300 mg in total) from Uther Peptide, shipped from China. At $270.00 for the kit, that works out to $0.90 per mg. Of the 4 PNC-27 listings on the marketplace, from 3 brands, this is the lowest price per mg. Funds stay in escrow and are released to Uther Peptide only when you mark the order as received.

What it is studied for

The proposed sequence of events begins at the cell surface. Several cancer cell lines are reported to display HDM-2 on their plasma membranes, and PNC-27 binds that surface protein through its p53-derived segment. The peptide is then thought to insert into the membrane, with modeling and electron microscopy suggesting transmembrane pore formation and rapid leakage of cell contents, a necrotic rather than apoptotic death. Untransformed cells, which show little membrane HDM-2 in these studies, appear largely spared in culture. Independent confirmation of the surface-HDM-2 model remains limited.

Research and regulatory status

Nearly all PNC-27 data come from cell-culture experiments using pancreatic, breast, leukemia and other cancer lines, most from a single group of investigators. No registered clinical trials have evaluated it, it is not an approved drug, and anecdotal reports online carry no weight as evidence. Research interest focuses on membrane-targeted cell-killing mechanisms rather than on any established therapeutic use, and claims of anticancer efficacy in people are unsupported.

Checking the lab data

Mass spectrometry should match the expected mass near 4032 Da for the full chimeric sequence; deletion products from either the p53 or penetratin segment would appear as lighter species. HPLC purity should be supported by a chromatogram rather than a single number. Because the peptide is strongly cationic and partly hydrophobic, counterion content and solubility observations are useful additions. Expect a white to off-white lyophilized cake.

This listing has an independent lab report attached; the testing panel above summarises what the tested sample contained against its label.

Listing details

Compound

PNC-27

Class

p53-derived membrane-lytic peptide

Format

Lyophilized (freeze-dried) powder

Molecular formula

C₁₈₈H₂₉₃N₅₃O₄₄S

Molecular weight

4031.7 g/mol

Vial strength

30mg

Vials per kit

10

Total content

300 mg

Price per mg

$0.90

Sold by

Uther Peptide

Ships from

China

Lab report

Independent report attached

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Concentration arithmetic: one 30 mg vial dissolved in 2 mL gives 15 mg/mL, or 30 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.