LL-37 5mg (10 Vials / Kit)

LL-37 at a glance

Humans encode just one cathelicidin gene, CAMP, and LL-37 is its main mature product. The precursor protein, hCAP18, is stored in neutrophil granules and expressed by skin and mucosal epithelia; proteinase 3 and related enzymes cleave it to free the active C-terminal peptide. LL-37 runs 37 residues, carries a strong net positive charge, and adopts an amphipathic alpha-helix in membrane-like environments. Its formula is listed as C205H340N60O53, with a molecular weight of 4493.37 g/mol.

Price and availability

A kit of 10 vials at 5mg each (50 mg in total) from Uther Peptide, shipped from China. $95.00 buys the whole kit, which is $1.90/mg. Across 8 brands listing LL-37 here, the middle half of prices falls between $1.84 and $1.84 per mg; this kit is above the typical range. As with every order here, the brand is paid only after you confirm delivery.

What it is studied for

Antimicrobial activity is generally attributed to electrostatic attraction between the cationic peptide and negatively charged bacterial membranes, followed by membrane thinning, pore formation or carpet-like disruption. LL-37 also binds lipopolysaccharide and lipoteichoic acid, which can blunt the inflammatory response those molecules trigger. Its signaling roles are broader: it has been reported to act on formyl peptide receptor 2, P2X7 and the epidermal growth factor receptor, influencing chemotaxis, cytokine release and epithelial migration. It can also complex with self-DNA, a property investigated in psoriasis and lupus research. Effects depend heavily on concentration and context.

Research and regulatory status

LL-37 is a model compound in antimicrobial-resistance and biofilm research and a frequent starting point for designing shorter synthetic derivatives. Studies span bacterial assays, cell culture, skin and wound models in animals, and a small number of early clinical investigations, including topical work on chronic leg ulcers. It is not an approved drug. Because it can damage host cells at higher concentrations and is linked to inflammatory skin conditions, its biological role is often described as double-edged.

Checking the lab data

A 37-residue cationic peptide is prone to truncation and deletion errors during synthesis, so mass spectrometry should show a deconvoluted mass close to 4493 Da without significant shorter species. HPLC purity should be reported with the chromatogram rather than as a bare figure. Peptide content matters because counterions such as trifluoroacetate can make up a notable share of the powder weight. Expect a white, fluffy lyophilized cake.

An independent lab report is attached to this listing, and the panel above shows the measured result next to the labelled amount.

Listing details

Compound

LL-37

Synonyms

Cathelicidin Antimicrobial Peptide (CAMP), hCAP18-derived peptide

Class

Human cathelicidin antimicrobial peptide

Format

Lyophilized (freeze-dried) powder

Molecular formula

C₂₀₅H₃₄₀N₆₀O₅₃

Molecular weight

4493.37 g/mol

Vial strength

5mg

Vials per kit

10

Total content

50 mg

Price per mg

$1.90

Sold by

Uther Peptide

Ships from

China

Lab report

Independent report attached

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Concentration arithmetic: one 5 mg vial dissolved in 2 mL gives 2.5 mg/mL, or 5 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.