FOX04 10mg (10 Vials / Kit)

FOXO4-DRI at a glance

FOXO4-DRI is built in an unusual way. Its sequence is based on part of the FOXO4 protein, but it is assembled from D-amino acids and in reverse order, an arrangement called retro-inverso. The approach keeps the side chains positioned much as they would be in the natural peptide while making the molecule resistant to the enzymes that usually break peptides down. With a listed molecular weight of about 5358 g/mol, it is larger than most research peptides.

Price and availability

Sold by Uther Peptide and sent from China, this listing is a kit of 10 vials at 10mg each (100 mg in total). The price is $350.00, or $3.50 per milligram of peptide. 3 brands currently sell FOXO4-DRI here, so compare their listings before ordering. Checkout goes into escrow first; the funds move to Uther Peptide once delivery is confirmed.

What it is studied for

Senescent cells stop dividing but resist dying, and in some of them the transcription factor FOXO4 holds the tumor suppressor p53 in the nucleus, keeping p53 from triggering apoptosis. FOXO4-DRI is designed to compete with FOXO4 for p53 binding. In the original experiments, this freed p53, which moved out of the nucleus and activated cell-death signaling in senescent cells, while non-senescent cells were reported to be much less affected. The selectivity, and whether it holds across cell types, is still under study.

Research and regulatory status

The concept was introduced in a 2017 paper that reported restored fitness, fur density and kidney function in naturally aged and fast-aging mice. Later studies have applied the peptide to senescence after chemotherapy, to aged testicular cells and to other aged-tissue models. All of this work is in animals and cell culture. FOXO4-DRI has not entered registered human trials and is not approved for any use.

Checking the lab data

A credible report for FOXO4-DRI gives a mass spectrometry result near the listed 5358 g/mol and HPLC purity with the chromatogram, to compare against the stated purity of at least 99%. Because the peptide uses D-amino acids, mass alone cannot distinguish it from an L-amino-acid version of the same sequence; chiral amino-acid analysis or a clear supplier statement on stereochemistry adds confidence. Measured content per vial and a white freeze-dried cake complete the profile.

This listing has an independent lab report attached; the testing panel above summarises what the tested sample contained against its label.

Listing details

Compound

FOXO4-DRI

Synonyms

FOXO4-D-Retro-Inverso peptide

Class

D-retro-inverso peptide (senolytic research tool)

Format

Lyophilized (freeze-dried) powder

Molecular weight

~5358 g/mol

Vial strength

10mg

Vials per kit

10

Total content

100 mg

Price per mg

$3.50

Sold by

Uther Peptide

Ships from

China

Lab report

Independent report attached

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Concentration arithmetic: one 10 mg vial dissolved in 2 mL gives 5 mg/mL, or 10 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.