Adipotide 10mg (10 Vials / Kit)

Adipotide at a glance

Adipotide, catalogued as FTPP, was designed by researchers at the University of Texas MD Anderson Cancer Center who used phage-display screening to find peptides that home to fat-tissue vasculature. The construct joins a cyclic targeting motif, CKGGRAKDC, to a pro-apoptotic sequence built from D-amino acids, D(KLAKLAK)2. The D-form backbone resists proteases, and the pro-apoptotic part is meant to act only after the targeting motif has carried it to the intended cells.

Price and availability

Sold by Uther Peptide and sent from China, this listing is a kit of 10 vials at 10mg each (100 mg in total). $165.00 buys the whole kit, which is $1.65/mg. Of the 5 Adipotide listings on the marketplace, from 4 brands, this is the lowest price per mg. As with every order here, the brand is paid only after you confirm delivery.

What it is studied for

The targeting motif is reported to bind prohibitin, a protein found on the surface of endothelial cells lining blood vessels in white adipose tissue, possibly in partnership with annexin A2. After binding, the conjugate is thought to be internalized, where the KLAKLAK domain disrupts mitochondrial membranes and sets off apoptosis in those endothelial cells. Loss of vascular supply is proposed to cause the fat cells downstream to shrink or die. The approach is therefore indirect, acting on vasculature rather than on adipocyte receptors or metabolic hormones.

Research and regulatory status

The founding mouse study reported fat loss in obese animals, and a later study in obese rhesus monkeys described reduced body weight, smaller waist measurements and improved insulin sensitivity. That primate work also recorded dose-dependent kidney changes, described as reversible, which shaped later discussion of the compound. Development as a human obesity treatment did not proceed, and Adipotide remains an unapproved experimental agent with no completed efficacy trials in people.

Checking the lab data

The two-domain structure makes identity testing especially important. Mass spectrometry should show a mass consistent with the full conjugate, expected near 2611 g/mol, and HPLC should show one dominant peak rather than separate targeting and effector fragments. Confirmation that the cyclic disulfide has formed, and of D-amino-acid content where the method allows, adds assurance. The lyophilized cake should be white and intact.

This listing has an independent lab report attached; the testing panel above summarises what the tested sample contained against its label.

Listing details

Compound

Adipotide

Synonyms

FTPP

Class

Proapoptotic peptidomimetic (fat-vasculature targeting)

Format

Lyophilized (freeze-dried) powder

Vial strength

10mg

Vials per kit

10

Total content

100 mg

Price per mg

$1.65

Sold by

Uther Peptide

Ships from

China

Lab report

Independent report attached

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Concentration arithmetic: one 10 mg vial dissolved in 2 mL gives 5 mg/mL, or 10 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.