Name: Orforglipron 6mg (100 Tablets)
Brand: TFC Peptides
SKU: TFC-ORF6
Price: 115.00 USD
Availability: InStock

Orforglipron at a glance

Orforglipron belongs to a newer generation of GLP-1 receptor agonists that are not peptides. It is a synthetic small molecule, originally discovered by Chugai Pharmaceutical and licensed to Eli Lilly, which has led its clinical development. Unlike semaglutide or liraglutide, it does not resemble the GLP-1 hormone structurally, and it was designed to be absorbed from the gut without the absorption enhancers that oral peptide products require. It is listed in the catalog as research material.

Price and availability

A kit of 100 vials at 6mg each (600 mg in total) from TFC Peptides, shipped from Tianjin, China. $115.00 buys the whole kit, which is $0.192/mg. TFC Peptides is currently the only brand on the marketplace selling Orforglipron. Checkout goes into escrow first; the funds move to TFC Peptides once delivery is confirmed.

This listing: TFC Peptides Orforglipron

Brand: TFC Peptides
Other strengths: 12mg $195.00

Lab testing

There is no public lab report for this listing yet. We can ask the brand for the batch COA before you order. Many buyers also split an independent HPLC test with others who bought the same batch.

Request the batch COA · How group testing works

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

What it is studied for

Orforglipron activates the GLP-1 receptor, the same target engaged by peptide incretin drugs, but it binds the receptor at a different site and in a different way from the native hormone. It is described as a biased agonist, favoring G-protein signaling and cyclic AMP production over recruitment of beta-arrestin. Downstream, GLP-1 receptor activation is studied for glucose-dependent insulin release, slower gastric emptying and reduced appetite signaling. Whether the biased profile changes outcomes compared with peptide agonists is an open research question.

Research and regulatory status

Lilly has run large Phase 3 clinical programs testing orforglipron in obesity and type 2 diabetes, and several of those trials have reported results. Its regulatory status has been changing as these data are reviewed, so check the current position with the relevant agency before citing it. Material listed on research marketplaces is not a licensed medicine and is not equivalent to any approved or pending product.

Checking the lab data

As a small molecule, orforglipron is analyzed differently from peptides. A credible report should confirm identity by LC-MS against the expected molecular mass, ideally supported by NMR or comparison with a reference standard, and give HPLC purity with the chromatogram. Content per vial or capsule against the label, residual solvent screening and a description of the powder's appearance are also relevant. Peptide-style amino-acid analysis does not apply here.

This listing has no third-party report on file yet. The lab reports directory and the marketplace show which brands do publish testing.

Listing details

Compound: Orforglipron
Vial strength: 6mg
Vials per kit: 100
Total content: 600 mg
Price per mg: $0.192
Sold by: TFC Peptides
Ships from: Tianjin, China
Lab report: Not yet published

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Concentration arithmetic: one 6 mg vial dissolved in 2 mL gives 3 mg/mL, or 6 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Why does it matter that orforglipron is not a peptide?

Peptides are generally broken down in the digestive tract, which is why most approved GLP-1 drugs are injectable products. A small molecule like orforglipron can be absorbed more readily and made by ordinary chemical synthesis rather than peptide manufacturing. For researchers, it also offers a structurally different tool for probing the same receptor.

Is orforglipron related to semaglutide?

Only by target. Both activate the GLP-1 receptor, but semaglutide is a modified version of the GLP-1 peptide hormone, while orforglipron is an entirely different chemical structure. They bind the receptor in different ways and are made by different processes, and data from one compound should not be assumed to apply to the other.

How much Orforglipron is in this listing?

100 vials of 6mg each — 600 mg in all. Where a lab report exists, the testing panel above shows what the brand's tested sample actually measured.

What if the parcel never arrives?

Open a claim from your order page. The payment is still in escrow at that point, so a claim decided in your favour is refunded to your Escrow Wallet.

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.