Orforglipron 12mg (100 Tablets)

Orforglipron at a glance

Orforglipron belongs to a newer generation of GLP-1 receptor agonists that are not peptides. It is a synthetic small molecule, originally discovered by Chugai Pharmaceutical and licensed to Eli Lilly, which has led its clinical development. Unlike semaglutide or liraglutide, it does not resemble the GLP-1 hormone structurally, and it was designed to be absorbed from the gut without the absorption enhancers that oral peptide products require. It is listed in the catalog as research material.

Price and availability

Sold by TFC Peptides and sent from Tianjin, China, this listing is a kit of 100 vials at 12mg each (1200 mg in total). At $195.00 for the kit, that works out to $0.163 per mg. TFC Peptides is currently the only brand on the marketplace selling Orforglipron. Funds stay in escrow and are released to TFC Peptides only when you mark the order as received.

What it is studied for

Orforglipron activates the GLP-1 receptor, the same target engaged by peptide incretin drugs, but it binds the receptor at a different site and in a different way from the native hormone. It is described as a biased agonist, favoring G-protein signaling and cyclic AMP production over recruitment of beta-arrestin. Downstream, GLP-1 receptor activation is studied for glucose-dependent insulin release, slower gastric emptying and reduced appetite signaling. Whether the biased profile changes outcomes compared with peptide agonists is an open research question.

Research and regulatory status

Lilly has run large Phase 3 clinical programs testing orforglipron in obesity and type 2 diabetes, and several of those trials have reported results. Its regulatory status has been changing as these data are reviewed, so check the current position with the relevant agency before citing it. Material listed on research marketplaces is not a licensed medicine and is not equivalent to any approved or pending product.

Checking the lab data

As a small molecule, orforglipron is analyzed differently from peptides. A credible report should confirm identity by LC-MS against the expected molecular mass, ideally supported by NMR or comparison with a reference standard, and give HPLC purity with the chromatogram. Content per vial or capsule against the label, residual solvent screening and a description of the powder's appearance are also relevant. Peptide-style amino-acid analysis does not apply here.

This listing has no third-party report on file yet. The lab reports directory and the marketplace show which brands do publish testing.

Listing details

Compound

Orforglipron

Vial strength

12mg

Vials per kit

100

Total content

1200 mg

Price per mg

$0.163

Sold by

TFC Peptides

Ships from

Tianjin, China

Lab report

Not yet published

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Concentration arithmetic: one 12 mg vial dissolved in 2 mL gives 6 mg/mL, or 12 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.