Humanin 10mg (10 Vials / Kit)

Humanin at a glance

Humanin was discovered by a Japanese research team led by Ikuo Nishimoto, who screened genetic material from a relatively spared region of an Alzheimer's disease patient's brain for factors that protected neurons from disease-related insults. The coding sequence lies within the mitochondrial 16S ribosomal RNA gene, making humanin one of the first recognized mitochondrial-derived peptides, a group that now includes MOTS-c. Research supplies are synthetic, and a more potent analog with a glycine substitution, often called HNG, is also common.

Price and availability

Sold by TFC Peptides and sent from Tianjin, China, this listing is a kit of 10 vials at 10mg each (100 mg in total). The price is $180.00, or $1.80 per milligram of peptide. Of the 2 Humanin listings on the marketplace, from 2 brands, this is the lowest price per mg. Your payment waits in escrow until you confirm the parcel arrived, and only then is it released to the brand.

What it is studied for

Humanin appears to work through more than one route. Outside cells, it is reported to bind formyl peptide receptor-like 1 and a three-part receptor complex involving CNTF receptor alpha, WSX-1 and gp130, activating STAT3 and other survival signaling. Inside cells, it has been described as interacting with the pro-apoptotic protein Bax and with IGF-binding protein 3, limiting programmed cell death. Studies also link it to insulin sensitivity and mitochondrial function. How these mechanisms relate to each other, and which dominate in living tissue, is not yet clear.

Research and regulatory status

Research on humanin is mostly preclinical, including neuronal culture models of amyloid toxicity, rodent studies of memory, stroke, heart injury and diabetes, and work on aging. Human data are observational: circulating levels have been reported to decline with age and to differ in some disease states and in families with exceptional longevity. No humanin-based product has completed clinical trials or received approval, and it remains a research compound.

Checking the lab data

Identity should be established by mass spectrometry matching the calculated mass of the specific sequence supplied, and the report should say whether the material is native humanin or an analog such as HNG, which differ in mass. Because the peptide can aggregate, HPLC purity with a full chromatogram and notes on solubility are useful. Peptide content per vial and a white, even lyophilized cake are expected.

This listing has no third-party report on file yet. The lab reports directory and the marketplace show which brands do publish testing.

Listing details

Compound

Humanin

Vial strength

10mg

Vials per kit

10

Total content

100 mg

Price per mg

$1.80

Sold by

TFC Peptides

Ships from

Tianjin, China

Lab report

Not yet published

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Concentration arithmetic: one 10 mg vial dissolved in 2 mL gives 5 mg/mL, or 10 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.