Abaloparatide 80µg Pen

Abaloparatide at a glance

Abaloparatide shares its opening sequence with human parathyroid hormone-related protein, the hormone that guides bone and cartilage development and is overproduced in humoral hypercalcemia of malignancy. Residues toward the C-terminal end of its 34-amino-acid chain were substituted to stabilize the helix and tune receptor binding, and the C-terminus is amidated. Developed by Radius Health under the code BA058, it is the active ingredient of an approved osteoporosis medicine.

Price and availability

This is TFC Peptides‘s single 80mcg vial, dispatched from Tianjin, China. $350.00 buys the whole kit, which is $4375.00/mg. 2 brands currently sell Abaloparatide here, so compare their listings before ordering. As with every order here, the brand is paid only after you confirm delivery.

What it is studied for

The PTH1 receptor can adopt at least two conformations. One, called RG, couples to G proteins only transiently, while the other, R0, supports prolonged signaling even after a ligand dissociates. Abaloparatide is reported to favor the RG state more selectively than teriparatide, producing shorter cyclic AMP responses. Researchers propose that this brief signal stimulates osteoblast bone formation while limiting the bone resorption and calcium mobilization associated with sustained PTH1R activity. The model comes largely from receptor pharmacology and animal studies, and how fully it explains clinical differences is still discussed.

Research and regulatory status

Large randomized trials in postmenopausal women with osteoporosis examined vertebral and nonvertebral fracture incidence and bone mineral density, and regulators in the United States and other markets approved the medicine on that basis; approval was later extended to men in some markets. Laboratory research continues on bone remodeling, fracture repair and PTH1R signaling. Research-grade vials are not the regulated pharmaceutical product, and clinical findings should not be read as describing them.

Checking the lab data

A credible report confirms the 34-residue sequence by mass spectrometry, matching the expected mass for the amidated peptide, and gives HPLC purity with its chromatogram. Because abaloparatide and teriparatide have similar lengths and the same receptor target, mass is the clearest way to tell them apart. Peptide content, batch number and test date from an independent lab round out the record. Expect a white lyophilized cake.

This listing has no third-party report on file yet. The lab reports directory and the marketplace show which brands do publish testing.

Listing details

Compound

Abaloparatide

Synonyms

BA058, ABL

Class

Synthetic parathyroid hormone-related protein (PTHrP) analog

Format

Lyophilized (freeze-dried) powder

Vial strength

80mcg

Total content

0.08 mg

Price per mg

$4375.00

Sold by

TFC Peptides

Ships from

Tianjin, China

Lab report

Not yet published

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.