Retatrutide 10mg

Retatrutide at a glance

Developed under the code LY3437943, retatrutide is a synthetic peptide built to act on three hormone receptors involved in nutrient handling: GLP-1, GIP and glucagon. A lipid side chain attached to the backbone lets it bind circulating albumin, which slows clearance and gives it a long duration of action in clinical pharmacology studies. Most other incretin-class candidates engage one or two of these receptors, so the three-way profile is what defines it. Listings ship as freeze-dried powder.

Price and availability

Peptide Express lists this single 10mg vial, shipped from the United States. $97.50 buys the whole kit, which is $9.75/mg. 28 brands sell Retatrutide on GLP1 Forum Escrow, with a typical price of $0.733–$4.20 per mg (median $1.00); this listing is above the typical range. Your payment waits in escrow until you confirm the parcel arrived, and only then is it released to the brand.

What it is studied for

Two of its three targets, the GLP-1 and GIP receptors, belong to the incretin system. Signaling through them is studied for glucose-dependent insulin release, slower movement of food out of the stomach and reduced hunger signaling in the brain. The third target sets retatrutide apart. Glucagon-receptor activity is proposed to raise energy expenditure and increase lipid oxidation in the liver, effects researchers are trying to separate from the incretin component. How the three signals balance at the receptor level, and how that balance shapes outcomes, remains an active question in the literature.

Research and regulatory status

Phase 2 trials in people with obesity, with type 2 diabetes and with fatty liver disease have been published, reporting large reductions in body weight and liver fat compared with placebo. Larger late-stage trials have followed, and their results continue to be reported. No regulator has approved retatrutide, so it remains an investigational drug, and long-term safety and outcome data are incomplete. Anyone citing the research should work from the primary trial publications rather than secondhand summaries.

Checking the lab data

A useful report for retatrutide gives a mass spectrometry result matching the expected molecular weight of roughly 4731 g/mol, which confirms the lipidated full-length peptide rather than a truncated or unmodified sequence. Alongside that, look for an HPLC purity figure with the chromatogram attached, the measured peptide content per vial compared with the label, and a note that the lyophilized cake is white and intact. The testing lab and batch number should be named.

This listing has no third-party report on file yet. The lab reports directory and the Retatrutide page show which brands do publish testing.

Listing details

Compound

Retatrutide

Synonyms

LY3437943

Class

Investigational triple GLP-1/GIP/glucagon receptor agonist

Format

Lyophilized (freeze-dried) powder

Molecular formula

C221H342N46O68

Molecular weight

~4731.3 g/mol

Vial strength

10mg

Total content

10 mg

Price per mg

$9.75

Sold by

Peptide Express

Ships from

United States

Lab report

Not yet published

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Concentration arithmetic: one 10 mg vial dissolved in 2 mL gives 5 mg/mL, or 10 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.