Name: VIP
Brand: Lilipeptide
SKU: LILI-vip
Availability: OutOfStock

Vasoactive Intestinal Peptide (VIP) at a glance

Vasoactive intestinal peptide was first isolated from porcine intestine by Sami Said and Viktor Mutt, who noticed its ability to widen blood vessels. It is a 28-amino-acid amidated peptide, sharing structural homology with secretin, glucagon, GHRH and especially PACAP. Neurons throughout the central and peripheral nervous systems synthesize it, and it is abundant in gut, airway and genitourinary innervation. Its listed formula is C147H238N44O43S, with a molecular weight of 3326.8 g/mol.

Price and availability

Lilipeptide lists this listing, shipped from China. It is listed at $95.00. Checkout goes into escrow first; the funds move to Lilipeptide once delivery is confirmed.

This listing: Lilipeptide Vasoactive Intestinal Peptide (VIP)

Brand: Lilipeptide
Also sold by: Uther Peptide 10mg $140.00 · HK Peptide 10mg $140.00 · TFC Peptides 10mg $140.00 · HK Peptide 5mg $75.00

Lab testing

There is no public lab report for this listing yet. We can ask the brand for the batch COA before you order. Many buyers also split an independent HPLC test with others who bought the same batch.

Request the batch COA · How group testing works

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

What it is studied for

VIP activates two class B G-protein-coupled receptors, VPAC1 and VPAC2, and binds the related PAC1 receptor only weakly. Both VPAC receptors couple mainly to Gs, raising cyclic AMP. In smooth muscle this produces relaxation, the basis of its vasodilatory and bronchodilatory reputation. In immune cells, VIP signaling is reported to dampen pro-inflammatory cytokines and favor regulatory T-cell responses. Within the suprachiasmatic nucleus, VIP-expressing neurons help synchronize circadian timekeeping, and mice lacking VIP or VPAC2 show disrupted rhythms. Rapid degradation by peptidases limits its persistence in the circulation.

Research and regulatory status

VIP has a long history as a laboratory hormone and as a marker in VIPoma, a rare tumor that overproduces it. Clinical investigation has examined inhaled forms for pulmonary hypertension and sarcoidosis, and an intravenous form, aviptadil, was studied in respiratory failure during the COVID-19 pandemic with inconclusive results. Aviptadil combined with phentolamine is approved in some European countries for erectile dysfunction. Elsewhere, VIP remains investigational, and its short half-life is a recurring obstacle.

Checking the lab data

A 28-residue peptide with a methionine and an amidated C-terminus needs both identity and integrity checks. Mass spectrometry should match the expected mass of about 3327 Da and reveal any oxidized methionine, which adds 16 Da. HPLC purity should be shown with its chromatogram, and peptide content helps when comparing listings per mg. The vial should contain a white lyophilized cake that looks dry and intact.

This listing has no third-party report on file yet. The lab reports directory and the marketplace show which brands do publish testing.

Listing details

Compound: Vasoactive Intestinal Peptide (VIP)
Synonyms: VIP
Class: Neuropeptide (secretin/glucagon peptide family)
Format: Lyophilized (freeze-dried) powder
Molecular formula: C147H238N44O43S
Molecular weight: 3326.8 g/mol
Sold by: Lilipeptide
Ships from: China
Lab report: Not yet published

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Buyer questions

How does VIP differ from PACAP?

PACAP, pituitary adenylate cyclase-activating polypeptide, shares much of VIP's sequence and activates VPAC1 and VPAC2 with similar potency. Unlike VIP, it also binds its own PAC1 receptor with high affinity. Because the two overlap, studies use receptor-selective tools to determine which peptide and receptor are responsible for an observed effect.

What is aviptadil?

Aviptadil is the international nonproprietary name for synthetic VIP used in clinical development and in certain approved combination products. It is chemically the same peptide as research-grade VIP, but pharmaceutical products are manufactured and regulated under different standards, so trial data on aviptadil do not transfer automatically to research material.

When does Lilipeptide get paid?

Only after you confirm delivery. Until then the payment is held in escrow, and you can open a claim if anything is wrong with the order.

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.