KPV 10mg (10 Vials / Kit)

KPV at a glance

KPV is three amino acids long: lysine, proline and valine, matching positions 11 to 13 at the carboxyl end of alpha-melanocyte-stimulating hormone. Alpha-MSH is cleaved from the larger precursor pro-opiomelanocortin, and early work found that this terminal fragment kept a portion of the hormone's anti-inflammatory activity. Its small size makes it simple to synthesize and characterize. Listings here supply KPV as a freeze-dried powder, and it also appears as one component of certain multi-peptide blends in the catalogue.

Price and availability

This is Lianhua Peptide Co.‘s kit of 10 vials at 10mg each (100 mg in total), dispatched from Hangzhou, China. The price is $47.70, or $0.477 per milligram of peptide. Of the 19 KPV listings on the marketplace, from 16 brands, this is the 2nd-lowest price per mg. Checkout goes into escrow first; the funds move to Lianhua Peptide Co. once delivery is confirmed.

What it is studied for

How much KPV depends on melanocortin receptors is unsettled, but pigment effects are not expected from such a short fragment. A leading proposal is that the proton-coupled di- and tripeptide transporter PepT1 carries it into epithelial and immune cells, where it interferes with NF-kB activation and lowers pro-inflammatory cytokine output in cell models. Some reports also describe antimicrobial effects. Nanoparticle and hydrogel formulations have been used in mouse colitis experiments to concentrate the peptide in inflamed intestinal tissue, though whether intracellular action explains all of its reported activity remains debated.

Research and regulatory status

Published work is preclinical: cultured intestinal epithelial cells, macrophage assays, keratinocyte and wound models, and chemically induced colitis in mice. Several groups have tested delivery systems to improve local exposure. No registered human clinical trial has established effects, and KPV is not an approved medicine anywhere we are aware of. Because uptake appears to depend on transporter expression, findings in one tissue may not carry over to another, a caution worth keeping in mind when reading summaries of this literature.

Checking the lab data

With only three residues, KPV gives a simple mass spectrum, so the observed mass should sit close to the calculated value for Lys-Pro-Val without stray peaks from protecting groups or truncated dipeptides. HPLC purity needs a visible chromatogram, because small hydrophilic peptides can elute early and hide impurities near the solvent front. The report should also note the counter-ion form, such as acetate, along with peptide content, a white lyophilized appearance and batch traceability.

This listing has no third-party report on file yet. The lab reports directory and the marketplace show which brands do publish testing.

Listing details

Compound

KPV

Synonyms

Lys-Pro-Val, alpha-MSH(11-13)

Class

Naturally occurring tripeptide, C-terminal alpha-MSH fragment

Format

Lyophilized (freeze-dried) powder

Vial strength

10mg

Vials per kit

10

Total content

100 mg

Price per mg

$0.477

Sold by

Lianhua Peptide Co.

Ships from

Hangzhou, China

Lab report

Not yet published

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Concentration arithmetic: one 10 mg vial dissolved in 2 mL gives 5 mg/mL, or 10 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.