Name: Semax 5mg (10 Vials / Kit)
Brand: TFC Peptides
SKU: TFC-XA5
Price: 35.00 USD
Availability: InStock

Semax at a glance

Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. Its first four residues match the 4-7 segment of adrenocorticotropic hormone, and the added Pro-Gly-Pro tail slows breakdown by peptidases. It was developed by researchers at the Institute of Molecular Genetics in Moscow. Although it descends from ACTH, it is not treated as a hormonal peptide, because the shortened sequence no longer carries the adrenal-stimulating activity of the parent molecule.

Price and availability

A kit of 10 vials at 5mg each (50 mg in total) from TFC Peptides, shipped from Tianjin, China. $35.00 buys the whole kit, which is $0.70/mg. Across 20 brands listing Semax here, the middle half of prices falls between $0.60 and $3.30 per mg; this kit is inside that range. Funds stay in escrow and are released to TFC Peptides only when you mark the order as received.

This listing: TFC Peptides Semax

Brand: TFC Peptides
Kit: 10 vials × 5 mg (50 mg in total)
Price per vial: $3.50
Price per mg: $0.70
Other strengths: 10mg $55.00 · 30mg $120.00
Also sold by: HK Peptide 5mg $40.00 · Imperial Peptides 5mg $28.00 · Cyprus Peptides 5mg $97.00 · Lilipeptide Semax $52.00 · Vital Edge Science Semax $45.00 · Peptide Express 10mg $40.00

Lab testing

There is no public lab report for this listing yet. We can ask the brand for the batch COA before you order. Many buyers also split an independent HPLC test with others who bought the same batch.

Request the batch COA · How group testing works

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

What it is studied for

Much of the mechanistic literature centers on neurotrophins. Rodent studies report that Semax raises levels of brain-derived neurotrophic factor and its receptor TrkB in the hippocampus and cortex, and gene-expression work after experimental ischemia describes shifts in inflammatory and vascular transcripts. Other papers propose effects on dopamine and serotonin turnover and possible interactions with melanocortin receptors, which would fit its ACTH ancestry. Antioxidant-like activity has also been described. How these observations connect, and which matter most, has not been settled, and the data come chiefly from animal tissue.

Research and regulatory status

Semax holds a different regulatory position from most catalogue peptides. Russian authorities list it as a registered medicine, supplied as nasal drops, and clinical reports from Russia cover stroke and cognitive disorders. Those studies are mostly small and published in Russian-language journals, which limits outside scrutiny. Semax has not been approved by the FDA or the EMA, and in the United States and Europe it is handled as an unapproved research compound with a largely preclinical evidence base.

Checking the lab data

Identity is best confirmed by mass spectrometry showing the mass expected for Met-Glu-His-Phe-Pro-Gly-Pro, with any N-acetyl or amidated variant stated explicitly when a vendor sells a modified form. HPLC purity should come from a chromatogram, not a bare figure. Because the sequence contains methionine, oxidized impurities are a known risk, so a clean main peak matters. Expect a white, intact lyophilized cake and a batch-matched, dated report.

No independent report is attached to this listing yet. You can compare brands that publish one on the Semax page or browse the lab reports directory.

Listing details

Compound: Semax
Synonyms: ACTH(4-10) analog
Class: Synthetic ACTH-fragment neuropeptide
Format: Lyophilized (freeze-dried) powder
Vial strength: 5mg
Vials per kit: 10
Total content: 50 mg
Price per mg: $0.70
Sold by: TFC Peptides
Ships from: Tianjin, China
Lab report: Not yet published

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Concentration arithmetic: one 5 mg vial dissolved in 2 mL gives 2.5 mg/mL, or 5 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

What is the difference between Semax and N-acetyl Semax?

N-acetyl Semax carries an acetyl group on the N-terminal methionine, a change intended to further slow enzymatic degradation. Some listings add an amide at the C-terminus as well. These are distinct molecules with different masses, so the analytical report should state exactly which form was tested.

Why does the Pro-Gly-Pro ending matter?

Short ACTH fragments are cleared by peptidases very quickly. The Pro-Gly-Pro extension was added to make the peptide more resistant to that breakdown, and the tripeptide itself has been studied separately for activity of its own. Its presence is one reason Semax persists long enough to be measured in tissue studies.

How much Semax is in this listing?

10 vials of 5mg each — 50 mg in all. Where a lab report exists, the testing panel above shows what the brand's tested sample actually measured.

What if the parcel never arrives?

Open a claim from your order page. The payment is still in escrow at that point, so a claim decided in your favour is refunded to your Escrow Wallet.

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.