ARA-290 16mg (10 Vials / Kit)

ARA-290 at a glance

Erythropoietin has two jobs: driving red blood cell production and, separately, protecting stressed tissue. ARA-290, given the nonproprietary name cibinetide, was designed by Araim Pharmaceuticals to capture the second role alone. Its 11 residues mimic the three-dimensional surface of EPO's helix B, a face that does not take part in hematopoietic receptor binding. Its reported molecular weight is around 1257 g/mol, and research material is supplied as a lyophilized powder.

Price and availability

A kit of 10 vials at 16mg each (160 mg in total) from Uther Peptide, shipped from China. $105.00 buys the whole kit, which is $0.656/mg. 4 brands sell ARA-290 on GLP1 Forum Escrow, with a typical price of $0.656–$0.85 per mg (median $0.85); this listing is inside that range. Checkout goes into escrow first; the funds move to Uther Peptide once delivery is confirmed.

What it is studied for

Hematopoietic signaling requires a homodimer of the EPO receptor. Tissue-protective signaling is attributed instead to a heteromeric complex in which the EPO receptor partners with the beta-common receptor, CD131, a combination called the innate repair receptor. This receptor is reported to be upregulated in injured or inflamed tissue. Engagement by cibinetide has been associated in animal models with reduced pro-inflammatory cytokine signaling, preservation of small nerve fibers and improved metabolic markers. The innate repair receptor model itself is still debated, and some researchers question whether CD131 is required in every tissue.

Research and regulatory status

Cibinetide has reached human trials, which sets it apart from most catalogue peptides. Small randomized studies in sarcoidosis-related small-fiber neuropathy and in diabetic neuropathy reported changes in corneal nerve fiber measures and symptom scores. No regulator has approved it, and larger confirmatory trials have not been published. Preclinical work continues in inflammation, retinopathy and metabolic-disease models, so it is best described as an investigational compound with early human data.

Checking the lab data

Mass spectrometry should return a mass close to the roughly 1257 g/mol cited for cibinetide, confirming the full sequence rather than a truncated or substituted peptide. Since catalogues sometimes print incomplete sequence strings, the report's sequence line deserves a careful read against the published structure. HPLC purity, the batch number and the test date from an independent lab complete the picture. The vial should contain a white lyophilized cake.

An independent lab report is attached to this listing, and the panel above shows the measured result next to the labelled amount.

Listing details

Compound

ARA-290

Synonyms

Cibinetide

Class

EPO-derived innate repair receptor agonist (11-amino-acid peptide)

Format

Lyophilized (freeze-dried) powder

Vial strength

16mg

Vials per kit

10

Total content

160 mg

Price per mg

$0.656

Sold by

Uther Peptide

Ships from

China

Lab report

Independent report attached

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Concentration arithmetic: one 16 mg vial dissolved in 2 mL gives 8 mg/mL, or 16 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.