Cortagen 20mg (10 Vials / Kit)

Cortagen at a glance

Cortagen is a four-residue synthetic peptide, Ala-Glu-Asp-Pro, sometimes abbreviated AEDP. It was created within Vladimir Khavinson's St. Petersburg bioregulator program, which derived short peptides from the amino-acid profiles of organ extracts. In this case the reference material was Cortexin, a polypeptide complex obtained from animal cerebral cortex and used clinically in Russia. Cortagen is intended as a defined, synthetic counterpart to that mixed extract, giving a single molecule to study.

Price and availability

This is Uther Peptide‘s kit of 10 vials at 20mg each (200 mg in total), dispatched from China. $150.00 buys the whole kit, which is $0.75/mg. 3 brands currently sell Cortagen here, so compare their listings before ordering. Your payment waits in escrow until you confirm the parcel arrived, and only then is it released to the brand.

What it is studied for

No specific receptor has been identified for Cortagen. Work from the originating group proposes that, like other short bioregulators, it acts at the level of gene expression, and microarray studies in rodent tissue report shifts in genes tied to cell proliferation, stress responses and cardiac function. In nerve-injury models, investigators describe changes consistent with faster regrowth of peripheral nerve fibers. How a tetrapeptide would reach and regulate specific genes remains unexplained, and the proposed mechanism lacks independent confirmation.

Research and regulatory status

Published studies are preclinical and few, mainly rodent experiments on sciatic nerve regeneration, neuroprotection markers and heart gene expression, plus some cell work. Nearly all come from Khavinson's network. There are no controlled human trials, Cortagen is not an approved medicine anywhere, and its findings have not been widely reproduced by outside groups. It is best treated as an exploratory compound with a thin evidence base.

Checking the lab data

A credible report should confirm Ala-Glu-Asp-Pro by mass spectrometry, matching the calculated mass for that sequence, and should name the sequence explicitly to avoid confusion with other short bioregulators. HPLC purity should be backed by a lot-specific chromatogram. Since the peptide lacks aromatic residues, detection relies on low-wavelength UV, so method details are worth checking. The lyophilized cake should be white.

This listing has an independent lab report attached; the testing panel above summarises what the tested sample contained against its label.

Listing details

Compound

Cortagen

Synonyms

AEDP peptide (Ala-Glu-Asp-Pro)

Class

Synthetic tetrapeptide bioregulator

Format

Lyophilized (freeze-dried) powder

Vial strength

20mg

Vials per kit

10

Total content

200 mg

Price per mg

$0.75

Sold by

Uther Peptide

Ships from

China

Lab report

Independent report attached

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Concentration arithmetic: one 20 mg vial dissolved in 2 mL gives 10 mg/mL, or 20 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.