Epithalon

Epitalon at a glance

Epitalon is a tetrapeptide with the sequence Ala-Glu-Asp-Gly, formula C14H22N4O9 and a molecular weight of 390.35 g/mol. Vladimir Khavinson's group in St. Petersburg synthesized it after analyzing the amino-acid composition of epithalamin, a pineal gland extract the group had been testing, intending a reproducible, chemically defined successor. Its small size makes it inexpensive to synthesize and simple to characterize, and it is among the most frequently listed of the bioregulator peptides.

Price and availability

Vital Edge Science lists this listing, shipped from Australia. It is listed at $78.00. Funds stay in escrow and are released to Vital Edge Science only when you mark the order as received.

What it is studied for

The most cited claim concerns telomerase. Work in cultured human fibroblasts and other cells reported increased expression of the catalytic telomerase subunit and longer telomeres after exposure, findings that have drawn attention but limited replication. A second thread involves the pineal gland: studies in aging animals describe restored nocturnal melatonin rhythms. The originating group also proposes that short peptides bind specific DNA sequences or histone proteins, altering chromatin accessibility and gene transcription. Changes in antioxidant enzymes have been reported too. Each of these is a hypothesis under investigation rather than a settled mechanism.

Research and regulatory status

Most studies were produced by the St. Petersburg Institute of Bioregulation and Gerontology and its collaborators: cell culture, rodent and fruit-fly lifespan experiments, and small human studies in older adults. Methodological detail in some of these papers is sparse, and large independent trials are absent. Epitalon is not approved as a medicine in the United States or the EU. Readers should weigh the literature as early-stage and concentrated within one research network.

Checking the lab data

With only four residues, Epitalon is easy to characterize but also easy to substitute. A credible report shows a mass-spectrometry result matching Ala-Glu-Asp-Gly, an HPLC chromatogram with the main peak clearly resolved and its purity stated, and a batch number tied to the vial. Look for a small, white, dense lyophilized cake. Results from an independent third-party lab carry more weight than a manufacturer's in-house sheet.

An independent lab report is attached to this listing, and the panel above shows the measured result next to the labelled amount.

Listing details

Compound

Epitalon

Synonyms

Epithalon, Epithalamin fragment

Class

Synthetic tetrapeptide bioregulator (Ala-Glu-Asp-Gly)

Format

Lyophilized (freeze-dried) powder

Molecular formula

C14H22N4O9

Molecular weight

390.35 g/mol

Sold by

Vital Edge Science

Ships from

Australia

Lab report

Independent report attached

Storage and preparation

Store sealed and as the label directs, away from heat and direct light. Discard anything with a broken seal or cloudy contents.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.