Name: LL37
Brand: Lilipeptide
SKU: LILI-ll37
Price: 110.00 USD
Availability: InStock

LL-37 at a glance

Humans encode just one cathelicidin gene, CAMP, and LL-37 is its main mature product. The precursor protein, hCAP18, is stored in neutrophil granules and expressed by skin and mucosal epithelia; proteinase 3 and related enzymes cleave it to free the active C-terminal peptide. LL-37 runs 37 residues, carries a strong net positive charge, and adopts an amphipathic alpha-helix in membrane-like environments. Its formula is listed as C205H340N60O53, with a molecular weight of 4493.37 g/mol.

Price and availability

Lilipeptide lists this listing, shipped from China. It is listed at $110.00. As with every order here, the brand is paid only after you confirm delivery.

This listing: Lilipeptide LL-37

Brand: Lilipeptide
Also sold by: Uther Peptide 5mg $95.00 · HK Peptide 5mg $75.00 · Lianhua Peptide Co. 5mg $91.81 · SSRBIO 5mg $91.81 · European Peptide Sciences 5mg $500.00 · Jinlu Peptides 5mg $275.41

Lab testing

There is no public lab report for this listing yet. We can ask the brand for the batch COA before you order. Many buyers also split an independent HPLC test with others who bought the same batch.

Request the batch COA · How group testing works

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

What it is studied for

Antimicrobial activity is generally attributed to electrostatic attraction between the cationic peptide and negatively charged bacterial membranes, followed by membrane thinning, pore formation or carpet-like disruption. LL-37 also binds lipopolysaccharide and lipoteichoic acid, which can blunt the inflammatory response those molecules trigger. Its signaling roles are broader: it has been reported to act on formyl peptide receptor 2, P2X7 and the epidermal growth factor receptor, influencing chemotaxis, cytokine release and epithelial migration. It can also complex with self-DNA, a property investigated in psoriasis and lupus research. Effects depend heavily on concentration and context.

Research and regulatory status

LL-37 is a model compound in antimicrobial-resistance and biofilm research and a frequent starting point for designing shorter synthetic derivatives. Studies span bacterial assays, cell culture, skin and wound models in animals, and a small number of early clinical investigations, including topical work on chronic leg ulcers. It is not an approved drug. Because it can damage host cells at higher concentrations and is linked to inflammatory skin conditions, its biological role is often described as double-edged.

Checking the lab data

A 37-residue cationic peptide is prone to truncation and deletion errors during synthesis, so mass spectrometry should show a deconvoluted mass close to 4493 Da without significant shorter species. HPLC purity should be reported with the chromatogram rather than as a bare figure. Peptide content matters because counterions such as trifluoroacetate can make up a notable share of the powder weight. Expect a white, fluffy lyophilized cake.

This listing has no third-party report on file yet. The lab reports directory and the marketplace show which brands do publish testing.

Listing details

Compound: LL-37
Synonyms: Cathelicidin Antimicrobial Peptide (CAMP), hCAP18-derived peptide
Class: Human cathelicidin antimicrobial peptide
Format: Lyophilized (freeze-dried) powder
Molecular formula: C₂₀₅H₃₄₀N₆₀O₅₃
Molecular weight: 4493.37 g/mol
Sold by: Lilipeptide
Ships from: China
Lab report: Not yet published

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Buyer questions

Why does LL-37 sometimes appear as a TFA salt?

Solid-phase synthesis and HPLC purification commonly use trifluoroacetic acid, which pairs with the peptide's many positively charged residues. The residual counterion adds weight and can affect cell-culture experiments, so some suppliers exchange it for acetate or chloride. An analytical report should state the salt form so that mass and per-mg comparisons are meaningful.

Is LL-37 related to the defensins?

Both are host-defense peptides of the innate immune system, but they belong to different structural families. Defensins are small peptides stabilized by disulfide bonds, whereas LL-37 lacks cysteines and relies on a flexible helix. They are often studied together because they are co-expressed in neutrophils and epithelial tissues.

When does Lilipeptide get paid?

Only after you confirm delivery. Until then the payment is held in escrow, and you can open a claim if anything is wrong with the order.

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.