PE-22-28 10mg (10 Vials / Kit)

PE-22-28 at a glance

PE-22-28 is a heptapeptide, Gly-Val-Ser-Trp-Gly-Leu-Arg, whose name records its position within the propeptide of sortilin, a receptor involved in protein sorting. When sortilin matures, its propeptide is released, and a 17-residue segment of it, called spadin, was found to have antidepressant-like activity in mice. A 2017 study set out to trim spadin to its shortest active portion, and PE-22-28 was among the fragments that came out of that work.

Price and availability

This is Uther Peptide‘s kit of 10 vials at 10mg each (100 mg in total), dispatched from China. At $80.00 for the kit, that works out to $0.80 per mg. 4 brands sell PE-22-28 on GLP1 Forum Escrow, with a typical price of $0.534–$0.54 per mg (median $0.54); this listing is above the typical range. Funds stay in escrow and are released to Uther Peptide only when you mark the order as received.

What it is studied for

TREK-1 is a two-pore-domain potassium channel that helps set neuronal excitability, and mice lacking the channel resist depression-like behavior in standard tests. Spadin binds and blocks TREK-1, and PE-22-28 is reported to do the same with greater potency in cells expressing the human channel. Blocking the channel is proposed to increase firing in mood-related circuits, including serotonergic neurons. Downstream, rodent studies describe increased hippocampal neurogenesis and changes in synaptic protein markers. Whether these findings translate beyond animal and cell systems is unknown.

Research and regulatory status

The evidence base is small and preclinical. The key papers come from a French research group that first described spadin and then its shortened analogs, using electrophysiology, behavioral tests in mice and measures of neurogenesis. They reported a quicker onset of effect than conventional antidepressants in those models. No human trials have been published, PE-22-28 holds no regulatory approval, and independent replication outside the originating group is limited.

Checking the lab data

Identity should be confirmed by mass spectrometry, with the observed mass matching the value calculated for GVSWGLR, and the report should state whether the C-terminus is a free acid or an amide, since vendors differ. HPLC purity needs a lot-specific chromatogram; the tryptophan residue makes UV detection straightforward. Net content per vial against the label is helpful, and the lyophilized cake should be white and even.

This listing has an independent lab report attached; the testing panel above summarises what the tested sample contained against its label.

Listing details

Compound

PE-22-28

Synonyms

Spadin analog, GVSWGLR

Class

Shortened spadin analog, TREK-1 channel inhibitor

Format

Lyophilized (freeze-dried) powder

Vial strength

10mg

Vials per kit

10

Total content

100 mg

Price per mg

$0.80

Sold by

Uther Peptide

Ships from

China

Lab report

Independent report attached

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Concentration arithmetic: one 10 mg vial dissolved in 2 mL gives 5 mg/mL, or 10 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.