IGF-1 LR3 1mg

IGF-1 LR3 at a glance

Long R3 IGF-1 is a recombinant variant of human insulin-like growth factor 1. It is 83 amino acids long: the native sequence with arginine in place of glutamic acid at position 3, plus a 13-residue extension at the N-terminus. The design came from Australian work aimed at a growth factor that performs well in culture media, where native IGF-1 is quickly captured by binding proteins. It is produced recombinantly, typically in bacterial expression systems.

Price and availability

A single 1mg vial from Lab77 Peptides, shipped from the United States. At $42.00 for the kit, that works out to $42.00 per mg. 11 brands sell IGF-1 LR3 on GLP1 Forum Escrow, with a typical price of $18.99–$35.00 per mg (median $20.00); this listing is above the typical range. Funds stay in escrow and are released to Lab77 Peptides only when you mark the order as received.

What it is studied for

IGF-1 normally circulates bound to a family of IGF-binding proteins that limit how much reaches its receptor. The R3 substitution and the extension sharply lower that binding, leaving more free ligand available. Free LR3 activates the IGF-1 receptor tyrosine kinase, recruiting insulin receptor substrates and engaging the PI3K-Akt-mTOR and Ras-MAPK pathways. In cultured cells these cascades are associated with proliferation, survival and increased protein synthesis. Receptor affinity itself is reported to be similar to or somewhat lower than native IGF-1, so the extra potency is attributed mainly to escape from binding proteins.

Research and regulatory status

IGF-1 LR3 is best established as a cell-culture supplement, used to support mammalian cell lines in biomanufacturing and to study myoblast and satellite-cell biology. Animal studies have explored its effects on growth and on gut tissue. It has never been developed as a medicine, no human efficacy trials exist, and it is not approved anywhere. Sports anti-doping rules prohibit IGF-1 and its analogs, which places LR3 on banned-substance lists.

Checking the lab data

As a recombinant protein rather than a short synthetic peptide, LR3 calls for mass spectrometry showing the intact mass expected for the 83-residue sequence, plus HPLC or SDS-PAGE purity. Endotoxin testing is relevant because of bacterial expression. A bioactivity assay in a responsive cell line adds confidence that the protein is correctly folded with proper disulfide bonds. The lyophilized cake should be white and uniform.

No independent report is attached to this listing yet. You can compare brands that publish one on the marketplace or browse the lab reports directory.

Listing details

Compound

IGF-1 LR3

Synonyms

Long R3 IGF-1

Class

Long-acting insulin-like growth factor 1 analog

Format

Lyophilized (freeze-dried) powder

Vial strength

1mg

Total content

1 mg

Price per mg

$42.00

Sold by

Lab77 Peptides

Ships from

United States

Lab report

Not yet published

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Concentration arithmetic: one 1 mg vial dissolved in 2 mL gives 0.5 mg/mL, or 1 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.