Retatrutide 50mg (10 Vials / Kit)

Retatrutide at a glance

Developed under the code LY3437943, retatrutide is a synthetic peptide built to act on three hormone receptors involved in nutrient handling: GLP-1, GIP and glucagon. A lipid side chain attached to the backbone lets it bind circulating albumin, which slows clearance and gives it a long duration of action in clinical pharmacology studies. Most other incretin-class candidates engage one or two of these receptors, so the three-way profile is what defines it. Listings ship as freeze-dried powder.

Price and availability

A kit of 10 vials at 50mg each (500 mg in total) from JP, shipped from Guangdong, China. The price is $320.00, or $0.64 per milligram of peptide. Across 28 brands listing Retatrutide here, the middle half of prices falls between $0.733 and $4.20 per mg; this kit is below the typical range, so among the cheaper options. Funds stay in escrow and are released to JP only when you mark the order as received.

What it is studied for

Two of its three targets, the GLP-1 and GIP receptors, belong to the incretin system. Signaling through them is studied for glucose-dependent insulin release, slower movement of food out of the stomach and reduced hunger signaling in the brain. The third target sets retatrutide apart. Glucagon-receptor activity is proposed to raise energy expenditure and increase lipid oxidation in the liver, effects researchers are trying to separate from the incretin component. How the three signals balance at the receptor level, and how that balance shapes outcomes, remains an active question in the literature.

Research and regulatory status

Phase 2 trials in people with obesity, with type 2 diabetes and with fatty liver disease have been published, reporting large reductions in body weight and liver fat compared with placebo. Larger late-stage trials have followed, and their results continue to be reported. No regulator has approved retatrutide, so it remains an investigational drug, and long-term safety and outcome data are incomplete. Anyone citing the research should work from the primary trial publications rather than secondhand summaries.

Checking the lab data

A useful report for retatrutide gives a mass spectrometry result matching the expected molecular weight of roughly 4731 g/mol, which confirms the lipidated full-length peptide rather than a truncated or unmodified sequence. Alongside that, look for an HPLC purity figure with the chromatogram attached, the measured peptide content per vial compared with the label, and a note that the lyophilized cake is white and intact. The testing lab and batch number should be named.

This listing has an independent lab report attached; the testing panel above summarises what the tested sample contained against its label.

Listing details

Compound

Retatrutide

Synonyms

LY3437943

Class

Investigational triple GLP-1/GIP/glucagon receptor agonist

Format

Lyophilized (freeze-dried) powder

Molecular formula

C221H342N46O68

Molecular weight

~4731.3 g/mol

Vial strength

50mg

Vials per kit

10

Total content

500 mg

Price per mg

$0.64

Sold by

JP

Ships from

Guangdong, China

Lab report

Independent report attached

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Concentration arithmetic: one 50 mg vial dissolved in 2 mL gives 25 mg/mL, or 50 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.