Name: FOXO4 10mg (10 Vials / Kit)
Brand: TFC Peptides
SKU: TFC-F410
Price: 315.00 USD
Availability: InStock

FOXO4-DRI at a glance

FOXO4-DRI is built in an unusual way. Its sequence is based on part of the FOXO4 protein, but it is assembled from D-amino acids and in reverse order, an arrangement called retro-inverso. The approach keeps the side chains positioned much as they would be in the natural peptide while making the molecule resistant to the enzymes that usually break peptides down. With a listed molecular weight of about 5358 g/mol, it is larger than most research peptides.

Price and availability

A kit of 10 vials at 10mg each (100 mg in total) from TFC Peptides, shipped from Tianjin, China. $315.00 buys the whole kit, which is $3.15/mg. 3 brands currently sell FOXO4-DRI here, so compare their listings before ordering. Your payment waits in escrow until you confirm the parcel arrived, and only then is it released to the brand.

This listing: TFC Peptides FOXO4

Brand: TFC Peptides
Kit: 10 vials × 10 mg (100 mg in total)
Price per vial: $31.50
Price per mg: $3.15

Lab testing

There is no public lab report for this listing yet. We can ask the brand for the batch COA before you order. Many buyers also split an independent HPLC test with others who bought the same batch.

Request the batch COA · How group testing works

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

What it is studied for

Senescent cells stop dividing but resist dying, and in some of them the transcription factor FOXO4 holds the tumor suppressor p53 in the nucleus, keeping p53 from triggering apoptosis. FOXO4-DRI is designed to compete with FOXO4 for p53 binding. In the original experiments, this freed p53, which moved out of the nucleus and activated cell-death signaling in senescent cells, while non-senescent cells were reported to be much less affected. The selectivity, and whether it holds across cell types, is still under study.

Research and regulatory status

The concept was introduced in a 2017 paper that reported restored fitness, fur density and kidney function in naturally aged and fast-aging mice. Later studies have applied the peptide to senescence after chemotherapy, to aged testicular cells and to other aged-tissue models. All of this work is in animals and cell culture. FOXO4-DRI has not entered registered human trials and is not approved for any use.

Checking the lab data

A credible report for FOXO4-DRI gives a mass spectrometry result near the listed 5358 g/mol and HPLC purity with the chromatogram, to compare against the stated purity of at least 99%. Because the peptide uses D-amino acids, mass alone cannot distinguish it from an L-amino-acid version of the same sequence; chiral amino-acid analysis or a clear supplier statement on stereochemistry adds confidence. Measured content per vial and a white freeze-dried cake complete the profile.

No independent report is attached to this listing yet. You can compare brands that publish one on the marketplace or browse the lab reports directory.

Listing details

Compound: FOXO4-DRI
Synonyms: FOXO4-D-Retro-Inverso peptide
Class: D-retro-inverso peptide (senolytic research tool)
Format: Lyophilized (freeze-dried) powder
Molecular weight: ~5358 g/mol
Vial strength: 10mg
Vials per kit: 10
Total content: 100 mg
Price per mg: $3.15
Sold by: TFC Peptides
Ships from: Tianjin, China
Lab report: Not yet published

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Concentration arithmetic: one 10 mg vial dissolved in 2 mL gives 5 mg/mL, or 10 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

What is a senolytic?

A senolytic is a compound that selectively kills senescent cells, which have permanently stopped dividing and accumulate in tissues with age. Researchers study senolytics to test whether removing these cells changes tissue function in aging and disease models. Approaches include small molecules and engineered peptides such as FOXO4-DRI, which target different survival pathways.

Why is FOXO4-DRI expensive compared with other peptides?

It is a long chain built entirely from D-amino acids, which cost more than the natural L-forms, and longer syntheses lose yield at each step. Purification is also more demanding. Comparing price per mg across brands on the marketplace, and checking each batch's report, helps separate genuine material from listings that look cheap for a reason.

How much FOXO4-DRI is in this listing?

10 vials of 10mg each — 100 mg in all. Where a lab report exists, the testing panel above shows what the brand's tested sample actually measured.

What if the parcel never arrives?

Open a claim from your order page. The payment is still in escrow at that point, so a claim decided in your favour is refunded to your Escrow Wallet.

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.