Name: IGF-1 LR3 0.1mg (10 Vials / Kit)
Brand: HK Peptide
SKU: HK-IG01
Price: 34.00 USD
Availability: InStock

IGF-1 LR3 at a glance

Long R3 IGF-1 is a recombinant variant of human insulin-like growth factor 1. It is 83 amino acids long: the native sequence with arginine in place of glutamic acid at position 3, plus a 13-residue extension at the N-terminus. The design came from Australian work aimed at a growth factor that performs well in culture media, where native IGF-1 is quickly captured by binding proteins. It is produced recombinantly, typically in bacterial expression systems.

Price and availability

Sold by HK Peptide and sent from Hong Kong, Hong Kong, this listing is a kit of 10 vials at 0.1mg each (1 mg in total). The price is $34.00, or $34.00 per milligram of peptide. 11 brands sell IGF-1 LR3 on GLP1 Forum Escrow, with a typical price of $18.99–$35.00 per mg (median $20.00); this listing is inside that range. As with every order here, the brand is paid only after you confirm delivery.

This listing: HK Peptide IGF-1 LR3

Brand: HK Peptide
Kit: 10 vials × 0.1 mg (1 mg in total)
Price per vial: $3.40
Other strengths: 1mg $200.00
Also sold by: TFC Peptides 0.1mg $35.00 · Cyprus Peptides 1mg $224.00 · Lab77 Peptides 1mg $42.00 · Uther Peptide 1mg $230.00 · TFC Peptides 1mg $180.00 · Sulan Bio 1mg $190.00

Lab testing

There is no public lab report for this listing yet. We can ask the brand for the batch COA before you order. Many buyers also split an independent HPLC test with others who bought the same batch.

Request the batch COA · How group testing works

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

What it is studied for

IGF-1 normally circulates bound to a family of IGF-binding proteins that limit how much reaches its receptor. The R3 substitution and the extension sharply lower that binding, leaving more free ligand available. Free LR3 activates the IGF-1 receptor tyrosine kinase, recruiting insulin receptor substrates and engaging the PI3K-Akt-mTOR and Ras-MAPK pathways. In cultured cells these cascades are associated with proliferation, survival and increased protein synthesis. Receptor affinity itself is reported to be similar to or somewhat lower than native IGF-1, so the extra potency is attributed mainly to escape from binding proteins.

Research and regulatory status

IGF-1 LR3 is best established as a cell-culture supplement, used to support mammalian cell lines in biomanufacturing and to study myoblast and satellite-cell biology. Animal studies have explored its effects on growth and on gut tissue. It has never been developed as a medicine, no human efficacy trials exist, and it is not approved anywhere. Sports anti-doping rules prohibit IGF-1 and its analogs, which places LR3 on banned-substance lists.

Checking the lab data

As a recombinant protein rather than a short synthetic peptide, LR3 calls for mass spectrometry showing the intact mass expected for the 83-residue sequence, plus HPLC or SDS-PAGE purity. Endotoxin testing is relevant because of bacterial expression. A bioactivity assay in a responsive cell line adds confidence that the protein is correctly folded with proper disulfide bonds. The lyophilized cake should be white and uniform.

No independent report is attached to this listing yet. You can compare brands that publish one on the marketplace or browse the lab reports directory.

Listing details

Compound: IGF-1 LR3
Synonyms: Long R3 IGF-1
Class: Long-acting insulin-like growth factor 1 analog
Format: Lyophilized (freeze-dried) powder
Vial strength: 0.1mg
Vials per kit: 10
Total content: 1 mg
Price per mg: $34.00
Sold by: HK Peptide
Ships from: Hong Kong, Hong Kong
Lab report: Not yet published

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Concentration arithmetic: one 0.1 mg vial dissolved in 2 mL gives 0.05 mg/mL, or 0.1 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Why does IGF-1 LR3 matter in biomanufacturing?

Cell lines used to produce proteins often need insulin or IGF-1 in serum-free media. Because LR3 is not tied up by the binding proteins those cells secrete, it stays active at lower concentrations than native IGF-1, which made it a practical media component and explains much of its early commercial use.

Is IGF-1 LR3 the same as mecasermin?

No. Mecasermin is recombinant IGF-1 with the native human sequence, approved for a specific growth disorder. LR3 is a structurally modified analog that has never gone through clinical development, so it shares a receptor target but not the approved medicine's identity, testing standards or regulatory status.

How much IGF-1 LR3 is in this listing?

10 vials of 0.1mg each — 1 mg in all. Where a lab report exists, the testing panel above shows what the brand's tested sample actually measured.

What if the parcel never arrives?

Open a claim from your order page. The payment is still in escrow at that point, so a claim decided in your favour is refunded to your Escrow Wallet.

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.