MOTS-C 20mg (10 Vials / Kit)

MOTS-c at a glance

Most peptides on the market derive from proteins coded in the cell nucleus. MOTS-c is an exception: a short open reading frame inside the mitochondrial 12S rRNA gene encodes it, which places it among the small group known as mitochondrial-derived peptides, alongside humanin. The chain is sixteen amino acids long, with a listed molecular weight of 2174.6 g/mol. Its discovery helped prompt the idea that mitochondria send hormone-like signals to the rest of the cell and body.

Price and availability

Sold by Uther Peptide and sent from China, this listing is a kit of 10 vials at 20mg each (200 mg in total). At $110.00 for the kit, that works out to $0.55 per mg. Across 21 brands listing MOTS-c here, the middle half of prices falls between $0.618 and $3.89 per mg; this kit is below the typical range, so among the cheaper options. Your payment waits in escrow until you confirm the parcel arrived, and only then is it released to the brand.

What it is studied for

Much of the interest centers on AMPK, the enzyme cells use to sense low energy. In cell and animal work, MOTS-c has been reported to interfere with the folate cycle, which leads to accumulation of the metabolite AICAR and, in turn, AMPK activation. Downstream, investigators have measured changes in glucose uptake by muscle and in insulin responsiveness. A second line of work describes the peptide moving into the nucleus under stress and interacting with transcription factors that control antioxidant and stress-response genes. These pathways are still being mapped, and their relevance in humans is unknown.

Research and regulatory status

The published record is preclinical. Mouse studies have looked at diet-induced obesity, insulin resistance, physical capacity in older animals and age-related metabolic changes, alongside a body of cell-culture work. Observational studies have measured natural MOTS-c levels in human blood, but the peptide itself has not completed controlled human trials as an intervention, and no regulator has approved it for any use. For now it is a laboratory research tool.

Checking the lab data

For MOTS-c, the key identity check is a mass spectrometry result close to the stated 2174.6 g/mol for the full sixteen-residue chain. HPLC purity should be reported with the chromatogram, and the measured content per vial compared against the label. Because the sequence contains methionine, a good report helps rule out oxidized variants, which show up as small mass shifts. The freeze-dried cake should be described as white and uniform, with no collapse or discoloration.

An independent lab report is attached to this listing, and the panel above shows the measured result next to the labelled amount.

Listing details

Compound

MOTS-c

Synonyms

Mitochondrial ORF of the 12S rRNA-c

Class

Mitochondrial-derived peptide (16 amino acids)

Format

Lyophilized (freeze-dried) powder

Molecular formula

C₁₀₁H₁₅₂N₂₈O₂₂S₂

Molecular weight

2174.6 g/mol

Vial strength

20mg

Vials per kit

10

Total content

200 mg

Price per mg

$0.55

Sold by

Uther Peptide

Ships from

China

Lab report

Independent report attached

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Concentration arithmetic: one 20 mg vial dissolved in 2 mL gives 10 mg/mL, or 20 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.