Argireline 10mg (10 Vials / Kit)

Argireline at a glance

Argireline is the trade name for an acetylated hexapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2, developed by the Spanish ingredient company Lipotec for skin-care formulations. Its sequence copies the N-terminal end of SNAP-25, a nerve-terminal protein involved in neurotransmitter release. On cosmetic labels it appears as acetyl hexapeptide-3 or, under a later naming update, acetyl hexapeptide-8. It is also the parent sequence from which the longer Snap-8 octapeptide was derived.

Price and availability

SSRBIO lists this kit of 10 vials at 10mg each (100 mg in total), shipped from China. $90.00 buys the whole kit, which is $0.90/mg. Of the 2 Argireline listings on the marketplace, from 2 brands, this is the lowest price per mg. Funds stay in escrow and are released to SSRBIO only when you mark the order as received.

What it is studied for

Release of acetylcholine at nerve-muscle junctions depends on the SNARE complex, a bundle of proteins including SNAP-25, syntaxin and synaptobrevin that drives vesicle fusion. Argireline is proposed to compete with SNAP-25 for a place in that complex, destabilizing its assembly and reducing neurotransmitter release in cell-based assays. Cosmetic research uses that mechanism to study expression lines in topical formulations. How much of the peptide crosses the skin barrier, and how large any effect is, remain subjects of debate.

Research and regulatory status

Studies are concentrated in cosmetic science and dermatology, using in vitro assays and small topical trials, several of them sponsored by ingredient makers. Argireline is regulated as a cosmetic ingredient rather than a drug and has no approved medical use. It is often used as a reference compound when newer SNARE-targeting peptides, such as Snap-8, are evaluated. Large independent controlled studies are limited.

Checking the lab data

A credible report should confirm the acetylated, amidated hexapeptide by mass spectrometry and give HPLC purity with its chromatogram. The mass separates Argireline from Snap-8, which is two residues longer. Because the sequence includes methionine, oxidation can appear as a small mass shift worth checking. Measured content, a description of the white powder, the salt form and a batch number linked to the listing should also be documented.

No independent report is attached to this listing yet. You can compare brands that publish one on the marketplace or browse the lab reports directory.

Listing details

Compound

Argireline

Vial strength

10mg

Vials per kit

10

Total content

100 mg

Price per mg

$0.90

Sold by

SSRBIO

Ships from

China

Lab report

Not yet published

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Concentration arithmetic: one 10 mg vial dissolved in 2 mL gives 5 mg/mL, or 10 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.