Dihexa 20mg (25 Tablets)

Dihexa at a glance

Dihexa, chemically N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is a small, capped peptide derivative that came out of Washington State University research on angiotensin IV analogues. Its developers modified the parent structure to make it more resistant to enzymatic degradation and better able to reach the brain in animal studies. Formally it is a short peptide mimetic rather than a natural peptide. Listings typically supply it as a powder for laboratory investigation, and published characterization outside the originating group is limited.

Price and availability

Sold by TFC Peptides and sent from Tianjin, China, this listing is a kit of 25 vials at 20mg each (500 mg in total). $120.00 buys the whole kit, which is $0.24/mg. Of the 4 Dihexa listings on the marketplace, from 2 brands, this is the lowest price per mg. As with every order here, the brand is paid only after you confirm delivery.

What it is studied for

Early angiotensin IV research proposed a dedicated AT4 binding site, later linked by some groups to insulin-regulated aminopeptidase. Dihexa's developers instead reported that it binds hepatocyte growth factor and promotes HGF dimerization, enhancing activation of the c-Met receptor tyrosine kinase. In neuronal cultures this was associated with increased dendritic spine formation and synaptogenesis, and in rodent models with reported changes on spatial learning tasks. Because c-Met signaling also drives cell proliferation and is implicated in some cancers, researchers note that long-term effects of potentiating this pathway are uncharacterized.

Research and regulatory status

Published data come mainly from a small number of papers by the originating group, using cell culture and rodent models of cognitive impairment. Dihexa has not completed human clinical trials and is not an approved medicine. A related HGF-modulating compound was later developed by a biotechnology company and tested in people, but it is a distinct molecule and its results do not transfer. Independent replication is limited, so Dihexa remains an early-stage research tool.

Checking the lab data

Identity should be confirmed by mass spectrometry matching the expected mass of the capped tyrosine-isoleucine-aminohexanoic amide structure, ideally supported by NMR because the molecule includes non-standard building blocks. HPLC purity with a chromatogram, residual solvent screening and a description of appearance should be included. Because Dihexa is relatively hydrophobic, the report should mention the solvent used for analysis. A batch number matching the label completes traceability.

This listing has no third-party report on file yet. The lab reports directory and the marketplace show which brands do publish testing.

Listing details

Compound

Dihexa

Vial strength

20mg

Vials per kit

25

Total content

500 mg

Price per mg

$0.24

Sold by

TFC Peptides

Ships from

Tianjin, China

Lab report

Not yet published

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Concentration arithmetic: one 20 mg vial dissolved in 2 mL gives 10 mg/mL, or 20 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.