Name: IGF-1 DES 2mg (10 Vials / Kit)
Brand: HK Peptide
SKU: HK-IGD
Price: 48.00 USD
Availability: InStock

IGF-1 DES at a glance

IGF-1 DES, written in the literature as des(1-3)IGF-1, is a 67-amino-acid peptide identical to human IGF-1 apart from lacking the N-terminal tripeptide Gly-Pro-Glu. Its molecular weight is about 7.4 kDa. The variant was first isolated from bovine colostrum and has since been detected in other tissues, including brain. Research supplies are produced recombinantly and lyophilized. The cleaved tripeptide, known as GPE, has been studied separately for activity of its own in neural models.

Price and availability

Sold by HK Peptide and sent from Hong Kong, Hong Kong, this listing is a kit of 10 vials at 2mg each (20 mg in total). At $48.00 for the kit, that works out to $2.40 per mg. Of the 3 IGF-1 DES listings on the marketplace, from 3 brands, this is the lowest price per mg. Funds stay in escrow and are released to HK Peptide only when you mark the order as received.

This listing: HK Peptide IGF-1 DES

Brand: HK Peptide
Kit: 10 vials × 2 mg (20 mg in total)
Price per vial: $4.80
Price per mg: $2.40
Also sold by: SSRBIO 1mg $108.00 · Jinlu Peptides 1mg $195.00

Lab testing

There is no public lab report for this listing yet. We can ask the brand for the batch COA before you order. Many buyers also split an independent HPLC test with others who bought the same batch.

Request the batch COA · How group testing works

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

What it is studied for

IGF-1 DES binds and activates the IGF-1 receptor in much the same way as the full-length hormone, triggering receptor autophosphorylation and downstream PI3K-Akt and MAPK signaling. The difference lies upstream: the missing residues include a glutamate that is important for contact with IGF-binding proteins. With that contact gone, far more of the peptide stays free to reach receptors, and cell assays report markedly higher apparent potency. Weaker binding-protein protection is also thought to shorten its persistence, favoring brief, local signaling.

Research and regulatory status

Research on IGF-1 DES is concentrated in cell culture and animal models, covering myoblast proliferation, muscle satellite cells, gut tissue and neural cells, with some interest in its natural role in the tissues where it was found. It has never entered clinical development, no human efficacy data exist, and it holds no regulatory approval. IGF-1 analogs as a group are prohibited under sports anti-doping rules.

Checking the lab data

Expect mass spectrometry showing an intact mass around 7.4 kDa, clearly distinguishable from full-length IGF-1, along with HPLC or SDS-PAGE purity. Because the material is recombinant, an endotoxin result is relevant. Correct disulfide pairing affects activity, so a cell-based bioassay or comparison against a reference standard strengthens confidence. The lyophilized powder should appear white and form an even cake.

No independent report is attached to this listing yet. You can compare brands that publish one on the marketplace or browse the lab reports directory.

Listing details

Compound: IGF-1 DES
Synonyms: IGF-1 DES(1-3), des(1-3)IGF-1, Truncated IGF-1
Class: Truncated insulin-like growth factor variant
Format: Lyophilized (freeze-dried) powder
Molecular weight: ~7.4 kDa
Vial strength: 2mg
Vials per kit: 10
Total content: 20 mg
Price per mg: $2.40
Sold by: HK Peptide
Ships from: Hong Kong, Hong Kong
Lab report: Not yet published

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Concentration arithmetic: one 2 mg vial dissolved in 2 mL gives 1 mg/mL, or 2 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Where was IGF-1 DES first found?

It was first purified from bovine colostrum, and a similar truncated form was later reported in human brain tissue. Its natural occurrence suggests the body itself trims IGF-1 in some settings, though how much of the circulating or tissue IGF-1 pool takes this form is still not well defined.

How does IGF-1 DES compare with IGF-1 LR3?

Both escape binding proteins, but by different routes. DES lacks three N-terminal residues and is shorter-lived, while LR3 adds an extension and an arginine substitution and is longer-acting. They share the IGF-1 receptor target but suit different experimental timeframes, and they are distinct molecules with different masses.

How much IGF-1 DES is in this listing?

10 vials of 2mg each — 20 mg in all. Where a lab report exists, the testing panel above shows what the brand's tested sample actually measured.

When does HK Peptide get paid?

Only after you confirm delivery. Until then the payment is held in escrow, and you can open a claim if anything is wrong with the order.

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.