Name: Pancragen 20mg (10 Vials / Kit)
Brand: Uther Peptide
SKU: UP-PANCRAGEN-20MG
Price: 150.00 USD
Availability: InStock

Pancragen at a glance

Pancragen, also called KEDW, is a synthetic tetrapeptide with the sequence Lys-Glu-Asp-Trp. It belongs to the family of short peptide bioregulators developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology, a group that designed tetrapeptides and tripeptides with reference to extracts from specific organs. Pancragen is the member linked to pancreatic tissue. It is small, water-soluble and made by standard peptide synthesis.

Price and availability

A kit of 10 vials at 20mg each (200 mg in total) from Uther Peptide, shipped from China. $150.00 buys the whole kit, which is $0.75/mg. 3 brands currently sell Pancragen here, so compare their listings before ordering. Funds stay in escrow and are released to Uther Peptide only when you mark the order as received.

This listing: Uther Peptide Pancragen

Brand: Uther Peptide
Kit: 10 vials × 20 mg (200 mg in total)
Price per vial: $15.00
Price per mg: $0.75
Also sold by: SSRBIO 20mg $141.00 · TFC Peptides 20mg $110.00

Lab testing

There is no public lab report for this listing yet. We can ask the brand for the batch COA before you order. Many buyers also split an independent HPLC test with others who bought the same batch.

Request the batch COA · How group testing works

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

What it is studied for

Like other members of this family, Pancragen has no identified cell-surface receptor. Its developers propose that short peptides enter cells and interact with DNA or histone proteins in promoter regions, altering gene transcription. In cultured pancreatic cells, reports describe changed expression of differentiation-related transcription factors, including PDX1, along with other markers of endocrine and exocrine cell identity. Those results come largely from the same laboratory network, and the chromatin-binding model has not been confirmed by independent structural or biochemical studies.

Research and regulatory status

The published record is limited and preclinical, consisting mainly of cell-culture experiments and aging-animal studies from Khavinson's network, often in Russian-language journals. Independent replication is sparse. Pancragen has not been evaluated in controlled human trials and is not an approved medicine. It is best regarded as an exploratory research compound with an uncertain mechanism, and claims that go beyond the cell-culture findings deserve caution.

Checking the lab data

Identity should be confirmed by mass spectrometry with the observed mass matching the value calculated for Lys-Glu-Asp-Trp. A sequence statement on the report matters here, because short bioregulator peptides are easy to confuse and catalogue entries sometimes list conflicting sequences. The tryptophan residue gives a strong UV signal for HPLC, so a clean main peak with stated purity is expected. The cake should be white and uniform.

This listing has no third-party report on file yet. The lab reports directory and the marketplace show which brands do publish testing.

Listing details

Compound: Pancragen
Synonyms: KEDW peptide (Lys-Glu-Asp-Trp)
Class: Synthetic tetrapeptide bioregulator
Format: Lyophilized (freeze-dried) powder
Vial strength: 20mg
Vials per kit: 10
Total content: 200 mg
Price per mg: $0.75
Sold by: Uther Peptide
Ships from: China
Lab report: Not yet published

Storage and preparation

Freeze-dried peptide keeps best sealed, cold and dark. Once it has been dissolved, refrigerate it, avoid repeated warming and follow the stability limits in your study protocol.

Concentration arithmetic: one 20 mg vial dissolved in 2 mL gives 10 mg/mL, or 20 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Who developed Pancragen?

It comes from Vladimir Khavinson's research program in St. Petersburg, which has produced a series of short peptides each linked to a particular organ, such as Cortagen for brain cortex and Pinealon for neural tissue. Most of the literature on Pancragen originates from that program and its collaborators.

Why is the evidence for Pancragen considered limited?

The studies are few, small and mostly from one network, and they rely on cell cultures and animal models. Its proposed mechanism, direct regulation of genes by a four-residue peptide, has not been independently confirmed. Together these points mean any reported effect should be treated as preliminary.

How much Pancragen is in this listing?

10 vials of 20mg each — 200 mg in all. Where a lab report exists, the testing panel above shows what the brand's tested sample actually measured.

When does Uther Peptide get paid?

Only after you confirm delivery. Until then the payment is held in escrow, and you can open a claim if anything is wrong with the order.

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.