Kisspeptin 10mg

Kisspeptin-10 at a glance

Kisspeptins are a family of peptides cut from a single precursor encoded by the KISS1 gene, which was first described in cancer research as a metastasis suppressor; the longest form was named metastin. Kisspeptin-10, also listed as KP-10 or metastin (45-54), is the C-terminal decapeptide shared by all of them, and its amidated terminus is essential for receptor binding. It is supplied here as freeze-dried powder for in vitro and animal research.

Price and availability

This is UWA Biotech‘s single 10mg vial, dispatched from the United States. At $42.00 for the kit, that works out to $4.20 per mg. 10 brands sell Kisspeptin-10 on GLP1 Forum Escrow, with a typical price of $0.80–$1.20 per mg (median $0.90); this listing is above the typical range. Funds stay in escrow and are released to UWA Biotech only when you mark the order as received.

What it is studied for

KP-10 is an agonist of KISS1R, a G protein-coupled receptor previously called GPR54. In the hypothalamus these receptors sit on GnRH neurons, and activation through Gq signaling depolarizes those cells and triggers GnRH release into the portal circulation. The pituitary then secretes LH and, to a lesser extent, FSH. Kisspeptin neurons in the arcuate nucleus are also thought to help generate GnRH pulses together with neurokinin B and dynorphin. Beyond reproduction, receptor expression in placenta, pancreas and blood vessels has prompted exploratory studies of other roles, which remain far less developed.

Research and regulatory status

The finding that loss-of-function mutations in the receptor cause failed puberty in humans made kisspeptin central to reproductive endocrinology. Since then, investigator-led human studies have infused kisspeptin peptides to probe LH responses, and some have explored their use in triggering egg maturation during assisted reproduction. Those studies are experimental, and kisspeptin-10 is not an approved drug. On this marketplace it is listed for laboratory use, where it serves mainly as a tool for testing receptor activity and hormone-axis responses.

Checking the lab data

Mass spectrometry should match the expected mass for the amidated decapeptide; a free-acid version differs by about one dalton and is a known synthesis error worth ruling out. Buyers should also check that the sequence printed on the report matches the published kisspeptin-10 sequence, since catalogue descriptions sometimes carry errors. HPLC purity with a chromatogram, peptide content, a white cake and a batch number matching the vial should all be present.

This listing has an independent lab report attached; the testing panel above summarises what the tested sample contained against its label.

Listing details

Compound

Kisspeptin-10

Synonyms

KP-10, Metastin (45-54)

Class

Reproductive-axis neuropeptide (decapeptide)

Format

Lyophilized (freeze-dried) powder

Vial strength

10mg

Total content

10 mg

Price per mg

$4.20

Sold by

UWA Biotech

Ships from

United States

Lab report

Independent report attached

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Concentration arithmetic: one 10 mg vial dissolved in 2 mL gives 5 mg/mL, or 10 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.