PEG-MGF 2mg (10 Vials / Kit)

PEG-MGF at a glance

Mechano growth factor is the name given to a splice variant of the insulin-like growth factor 1 gene, called IGF-1Ec in humans, whose expression rises in muscle after mechanical loading or damage. The variant differs from mature IGF-1 in its C-terminal E domain, and research peptides labeled MGF reproduce that unique E-domain segment rather than the whole protein. PEG-MGF attaches a polyethylene glycol chain to this peptide, a modification intended to slow degradation and extend its persistence in experimental systems.

Price and availability

This is SSRBIO‘s kit of 10 vials at 2mg each (20 mg in total), dispatched from China. At $74.93 for the kit, that works out to $3.75 per mg. Across 4 brands listing PEG-MGF here, the middle half of prices falls between $3.75 and $3.75 per mg; this kit is inside that range. Checkout goes into escrow first; the funds move to SSRBIO once delivery is confirmed.

What it is studied for

The MGF E-domain peptide is proposed to act independently of the IGF-1 receptor, although its own receptor has not been identified. Early cell studies reported that it stimulates proliferation of muscle precursor cells, including satellite cells and myoblasts, while delaying their fusion into myotubes, a pattern distinct from mature IGF-1. Other work described neuroprotective and cardioprotective effects in injury models. PEGylation is thought to shield the peptide from proteases and reduce renal clearance. Several later studies, however, failed to reproduce the proliferative effect, so the biological activity of synthetic E-peptides is contested.

Research and regulatory status

Research on MGF and its PEGylated form consists of cell-culture and animal studies, mostly in muscle, bone, cartilage and cardiac injury models. No controlled human trials have been published, and the compound has no regulatory approval. Anti-doping rules list mechano growth factors among prohibited growth factors. The conflicting replication record means findings from one laboratory should not be generalized, and PEG chain size often goes unreported, complicating comparisons.

Checking the lab data

PEGylation complicates analysis. Polyethylene glycol is polydisperse, so mass spectrometry usually shows a broad distribution of masses rather than a single peak, and the report should state the PEG chain size and what was observed. HPLC should indicate how much unconjugated peptide or free PEG is present. A report showing only the mass of the bare E-peptide would suggest the conjugate is missing. Expect a white lyophilized cake.

No independent report is attached to this listing yet. You can compare brands that publish one on the marketplace or browse the lab reports directory.

Listing details

Compound

PEG-MGF

Vial strength

2mg

Vials per kit

10

Total content

20 mg

Price per mg

$3.75

Sold by

SSRBIO

Ships from

China

Lab report

Not yet published

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Concentration arithmetic: one 2 mg vial dissolved in 2 mL gives 1 mg/mL, or 2 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.