P-21 5mg (10 Vials / Kit)

P-21 at a glance

P-21, more often written P021 in the literature, is a small synthetic peptidomimetic developed by Khalid Iqbal's group at the New York State Institute for Basic Research in Developmental Disabilities. It was derived from a biologically active region of ciliary neurotrophic factor, a neurotrophic cytokine, and modified with an adamantane-containing residue intended to improve stability, lipophilicity and brain penetration. The goal was a compound small enough to reach the brain in animal studies, unlike the full-length protein.

Price and availability

A kit of 10 vials at 5mg each (50 mg in total) from SSRBIO, shipped from China. At $252.00 for the kit, that works out to $5.04 per mg. 3 brands currently sell P-21 here, so compare their listings before ordering. As with every order here, the brand is paid only after you confirm delivery.

What it is studied for

Studies from the developing group report that P021 increases expression of brain-derived neurotrophic factor in the hippocampus and promotes neurogenesis in the dentate gyrus of rodents. It is also described as antagonizing leukemia inhibitory factor signaling, which would favor neuronal over glial differentiation of progenitor cells. In transgenic Alzheimer's models, reported downstream effects include reduced tau hyperphosphorylation, linked to inhibition of glycogen synthase kinase-3 beta, and less amyloid pathology. These pathways are interconnected, and which one drives the observed effects has not been resolved.

Research and regulatory status

Evidence comes from rodent studies, including transgenic Alzheimer's disease mice, aged rats and a mouse model of Down syndrome, mostly published by the originating laboratory and its collaborators. Reported outcomes include better performance on learning tasks and preserved synaptic markers. There are no registered human trials, and the compound is not approved anywhere. Independent replication is limited, so the findings are best regarded as preliminary.

Checking the lab data

Because P021 contains a non-standard adamantane-modified residue, a credible report needs mass spectrometry matching the expected mass of the full modified structure, not just the parent CNTF fragment. HPLC purity should be shown with a chromatogram. The report should name the compound as P021 or provide its structure, since P-21 is also used for unrelated substances, including the p21 cell-cycle protein. Expect a white lyophilized powder.

This listing has no third-party report on file yet. The lab reports directory and the marketplace show which brands do publish testing.

Listing details

Compound

P-21

Vial strength

5mg

Vials per kit

10

Total content

50 mg

Price per mg

$5.04

Sold by

SSRBIO

Ships from

China

Lab report

Not yet published

Storage and preparation

Keep unopened freeze-dried vials cold, sealed and out of the light; moisture is what degrades a lyophilized cake fastest. After reconstitution, refrigerate the solution and work within the stability window your protocol sets.

Concentration arithmetic: one 5 mg vial dissolved in 2 mL gives 2.5 mg/mL, or 5 mg/mL in 1 mL. The Research Lab calculator in your dashboard handles any other volume.

Buyer questions

Supplied for laboratory research only. Not for human or veterinary use, and not a substitute for any prescription medicine. Nothing on this page is medical advice.